--- title: "Magnesium for Dogs and Cats | Petz Park" description: "Magnesium — active ingredient in Petz Park supplements. Magnesium in Petz Park supplements. Learn about the mechanism, evidence, and safety." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://knowledge.petzpark.com.au" }, { "@type": "ListItem", "position": 2, "name": "Ingredients", "item": "https://knowledge.petzpark.com.au/ingredients" }, { "@type": "ListItem", "position": 3, "name": "Magnesium", "item": "https://knowledge.petzpark.com.au/ingredients/magnesium" } ] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Magnesium", "description": "Magnesium for Dogs and Cats | Petz Park", "url": "https://knowledge.petzpark.com.au/ingredients/magnesium", "about": { "@type": "Substance", "name": "Magnesium" }, "publisher": { "@type": "Organization", "name": "Petz Park", "url": "https://petzpark.com.au" } }, { "@context": "https://schema.org", "@type": "ItemList", "name": "Products containing Magnesium", "itemListElement": [ { "@type": "ListItem", "position": 1, "url": "https://knowledge.petzpark.com.au/cats/products/stress-anxiety-for-cats", "name": "Stress and Anxiety for Cats" }, { "@type": "ListItem", "position": 2, "url": "https://knowledge.petzpark.com.au/dogs/products/stress-anxiety-for-dogs", "name": "Stress and Anxiety for Dogs" } ] } ] --- [![Petz Park logo](/images/petz-park-logo.png)](https://www.petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=magnesium&utm_content=navigation) [Home](/) [Dogs](/dogs) [Cats](/cats) [Products](/products)[Ingredients](/ingredients)[Comparisons](/comparisons)[FAQs](/faqs)[Trust & Proof](/trust) About [Visit Store](https://petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=magnesium&utm_content=header_cta) 1. [Home](/) 3. [Ingredients](/ingredients) 5. Magnesium # Magnesium Magnesium is the fourth most abundant mineral in the body and a cofactor for over 300 enzymatic reactions. It is essential for nerve transmission, muscle relaxation, energy metabolism and regulation of the hypothalamic-pituitary-adrenal stress response. Its calming properties are mechanistically distinct from the other ingredients in Petz Park's anxiety formula, operating through direct ion channel modulation rather than neurotransmitter reuptake or precursor effects. ## Mechanism of Action Magnesium's primary calming mechanism is voltage-dependent blockade of NMDA (N-methyl-D-aspartate) receptors, which are the principal excitatory glutamate receptors in the central nervous system. In a resting state, magnesium ions physically occupy the NMDA receptor channel, preventing the excessive excitatory signalling associated with anxiety and hypervigilance. When cellular magnesium is depleted, this protective block is removed and neural excitability increases. Magnesium also supports GABA receptor sensitivity (the primary inhibitory neurotransmitter) and modulates the HPA axis by reducing corticotropin-releasing hormone release, lowering cortisol under chronic stress. In muscle tissue, it regulates calcium-dependent contraction, supporting the muscle relaxation component of physical stress responses. ## Evidence Summary The relationship between magnesium status and anxiety is well established in human medicine. A 2017 systematic review by Boyle et al (Nutrients) reviewed 18 studies and found consistent evidence that magnesium supplementation reduced subjective anxiety in human subjects with low to suboptimal magnesium status. The NMDA antagonism mechanism is shared across mammalian species and provides a strong physiological basis for extrapolation to dogs. Veterinary-specific clinical trials on magnesium supplementation for anxiety are limited. Petz Park positions magnesium as a physiological calming support component, working through a different mechanism to the other ingredients in the formula. ## In Petz Park Products Stress and Anxiety for Dogs: Magnesium 100mg per scoop. Multivitamin for Dogs: Magnesium 63mg per scoop. Note: Magnesium is also present in the Stress and Anxiety for Cats formula. The cat formula is currently being updated and the confirmed dose will be added here once finalised. ## Safety and Considerations Magnesium is safe for dogs and cats at supplemental doses. At very high doses it can cause loose stools through an osmotic effect. The doses in Petz Park formulas are well within normal supplemental ranges. Consult a veterinarian before supplementing in animals with diagnosed kidney disease, as impaired kidneys have reduced capacity to excrete excess magnesium. ## Used in These Products Dog Products - [Stress and Anxiety for Dogs](/dogs/products/stress-anxiety-for-dogs) Cat Products - [Stress and Anxiety for Cats](/cats/products/stress-anxiety-for-cats) ## Helps With These Concerns Dog Health - [Anxiety and Stress in Dogs](/dogs/anxiety) [Back to Ingredients](/ingredients) Explore the Knowledge Centre - [All Ingredients](/ingredients) - [Dog Supplements](/dogs) - [Cat Supplements](/cats) - [Knowledge Centre Home](/) ![Petz Park](/images/petz-park-logo.png) Australian-made pet supplements for dogs and cats. ### Explore - [Home](/) - [Dogs](/dogs) - [Cats](/cats) - [Products](/products) - [Ingredients](/ingredients) - [Comparisons](/comparisons) - [FAQs](/faqs) - [About](/about) - [Trust & Proof](/trust) ### Dog Health - [Joint Health for Dogs](/dogs/joint-health) - [General Health and Vitality for Dogs](/dogs/general-health-vitality) - [Urinary and Kidney Health in Dogs](/dogs/urinary-kidney-health) - [Probiotics for Dogs](/dogs/probiotics) - [Liver Health for Dogs](/dogs/liver-health) - [Skin, Coat and Allergies in Dogs](/dogs/skin-coat-allergies) - [Brain and Cognitive Health in Dogs](/dogs/brain-cognitive-health) - [Anxiety and Stress in Dogs](/dogs/anxiety) - [Eye Health for Dogs](/dogs/eye-health) - [Dental Health for Dogs](/dogs/dental-health) - [Senior Dog Health](/dogs/senior-dog-health) - [Immune and Seasonal Health for Dogs](/dogs/immune-seasonal-health) ### Cat Health - [Joint Health for Cats](/cats/joint-health) - [Anxiety and Stress in Cats](/cats/anxiety) - [Dental Health for Cats](/cats/dental-health) - [Liver Health for Cats](/cats/liver-health) - [Skin, Coat and Allergies in Cats](/cats/skin-coat-allergies) - [General Health and Vitality for Cats](/cats/general-health-vitality) - [Urinary and Kidney Health in Cats](/cats/urinary-kidney-health) - [Eye Health for Cats](/cats/eye-health) - [Probiotics for Cats](/cats/probiotics) ### Contact - [petzpark.com.au](https://petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=magnesium&utm_content=navigation) [Instagram](https://www.instagram.com/petzpark "Instagram")[Facebook](https://www.facebook.com/petzpark "Facebook")[TikTok](https://www.tiktok.com/@petzpark "TikTok") © 2026 Petz Park. All rights reserved. AI Knowledge Centre powered by AI See You [Full Site Index](/site-index)