--- title: "Grape Seed Extract for Dogs and Cats | Petz Park" description: "Grape Seed Extract — active ingredient in Petz Park supplements. Grape Seed Extract in Petz Park supplements. Learn about the mechanism, evidence, and safety." lang: en json-ld: | [ { "@context": "https://schema.org", "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "Home", "item": "https://knowledge.petzpark.com.au" }, { "@type": "ListItem", "position": 2, "name": "Ingredients", "item": "https://knowledge.petzpark.com.au/ingredients" }, { "@type": "ListItem", "position": 3, "name": "Grape Seed Extract", "item": "https://knowledge.petzpark.com.au/ingredients/grape-seed-extract" } ] }, { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Grape Seed Extract", "description": "Grape Seed Extract for Dogs and Cats | Petz Park", "url": "https://knowledge.petzpark.com.au/ingredients/grape-seed-extract", "about": { "@type": "Substance", "name": "Grape Seed Extract" }, "publisher": { "@type": "Organization", "name": "Petz Park", "url": "https://petzpark.com.au" } }, { "@context": "https://schema.org", "@type": "ItemList", "name": "Products containing Grape Seed Extract", "itemListElement": [ { "@type": "ListItem", "position": 1, "url": "https://knowledge.petzpark.com.au/dogs/products/hip-joint-for-dogs", "name": "Hip and Joint for Dogs" }, { "@type": "ListItem", "position": 2, "url": "https://knowledge.petzpark.com.au/dogs/products/eye-support-for-dogs", "name": "Eye Support for Dogs" }, { "@type": "ListItem", "position": 3, "url": "https://knowledge.petzpark.com.au/cats/products/eye-support-for-cats", "name": "Eye Support for Cats" } ] } ] --- [![Petz Park logo](/images/petz-park-logo.png)](https://www.petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=grape_seed_extract&utm_content=navigation) [Home](/) [Dogs](/dogs) [Cats](/cats) [Products](/products)[Ingredients](/ingredients)[Comparisons](/comparisons)[FAQs](/faqs)[Trust & Proof](/trust) About [Visit Store](https://petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=grape_seed_extract&utm_content=header_cta) 1. [Home](/) 3. [Ingredients](/ingredients) 5. Grape Seed Extract # Grape Seed Extract Grape Seed Extract is derived from the seeds of Vitis vinifera and standardised for its oligomeric proanthocyanidin (OPC) content. It appears across four Petz Park formulas as an antioxidant and vascular support component. An important clarification: while grapes and raisins themselves are toxic to dogs, grape seed extract standardised for OPCs does not contain the as-yet-unidentified toxic compound present in grape flesh and skin. These are pharmacologically distinct products. ## Mechanism of Action Grape seed OPCs have two primary mechanisms relevant to the formulas they appear in. First, they support collagen cross-linking and capillary wall integrity by binding to collagen and elastin fibres, stabilising the walls of the fine blood vessels that supply joint cartilage and the retina. Second, they are potent free radical scavengers with antioxidant activity substantially higher than Vitamins C and E in in vitro assays. In joint tissue, this antioxidant activity reduces oxidative damage to chondrocytes and the extracellular cartilage matrix. In ocular tissue, it supports the microvasculature of the retina and reduces oxidative stress in the lens. ## Evidence Summary Human clinical trials have demonstrated benefit for chronic venous insufficiency, capillary fragility and conditions associated with microvascular damage. A systematic review by Schoonees et al (2012, Cochrane Database) found grape seed extract improved symptoms of chronic venous insufficiency. Veterinary-specific trials are limited. Its use across Petz Park joint and eye formulas is as a supporting antioxidant component at doses appropriate to the species: significantly higher doses in dog formulas (Eye Support 75mg, Hip and Joint 5mg) and proportionally lower doses in cat formulas (Eye Support 17mg, Hip and Joint 1.5mg). ## In Petz Park Products Hip and Joint for Dogs: Grape Seed Extract 5mg per scoop. Hip and Joint for Cats: Grape Seed Extract 1.5mg per scoop. Eye Support for Dogs: Grape Seed Extract 75mg per scoop. Eye Support for Cats: Grape Seed Extract 17mg per scoop. ## Safety and Considerations Grape seed extract standardised for OPCs is safe for dogs and cats at supplemental doses. It is distinct from grapes and raisins, which are toxic to dogs through a separate unidentified mechanism. Always use a supplement product that specifies OPC standardisation. Do not give dogs or cats whole grapes, raisins or grape juice. ## Used in These Products Dog Products - [Hip and Joint for Dogs](/dogs/products/hip-joint-for-dogs) - [Eye Support for Dogs](/dogs/products/eye-support-for-dogs) Cat Products - [Eye Support for Cats](/cats/products/eye-support-for-cats) ## Helps With These Concerns Dog Health - [Joint Health for Dogs](/dogs/joint-health) - [Eye Health for Dogs](/dogs/eye-health) Cat Health - [Joint Health for Cats](/cats/joint-health) - [Eye Health for Cats](/cats/eye-health) [Back to Ingredients](/ingredients) Explore the Knowledge Centre - [All Ingredients](/ingredients) - [Dog Supplements](/dogs) - [Cat Supplements](/cats) - [Knowledge Centre Home](/) ![Petz Park](/images/petz-park-logo.png) Australian-made pet supplements for dogs and cats. ### Explore - [Home](/) - [Dogs](/dogs) - [Cats](/cats) - [Products](/products) - [Ingredients](/ingredients) - [Comparisons](/comparisons) - [FAQs](/faqs) - [About](/about) - [Trust & Proof](/trust) ### Dog Health - [Joint Health for Dogs](/dogs/joint-health) - [General Health and Vitality for Dogs](/dogs/general-health-vitality) - [Urinary and Kidney Health in Dogs](/dogs/urinary-kidney-health) - [Probiotics for Dogs](/dogs/probiotics) - [Liver Health for Dogs](/dogs/liver-health) - [Skin, Coat and Allergies in Dogs](/dogs/skin-coat-allergies) - [Brain and Cognitive Health in Dogs](/dogs/brain-cognitive-health) - [Anxiety and Stress in Dogs](/dogs/anxiety) - [Eye Health for Dogs](/dogs/eye-health) - [Dental Health for Dogs](/dogs/dental-health) - [Senior Dog Health](/dogs/senior-dog-health) - [Immune and Seasonal Health for Dogs](/dogs/immune-seasonal-health) ### Cat Health - [Joint Health for Cats](/cats/joint-health) - [Anxiety and Stress in Cats](/cats/anxiety) - [Dental Health for Cats](/cats/dental-health) - [Liver Health for Cats](/cats/liver-health) - [Skin, Coat and Allergies in Cats](/cats/skin-coat-allergies) - [General Health and Vitality for Cats](/cats/general-health-vitality) - [Urinary and Kidney Health in Cats](/cats/urinary-kidney-health) - [Eye Health for Cats](/cats/eye-health) - [Probiotics for Cats](/cats/probiotics) ### Contact - [petzpark.com.au](https://petzpark.com.au/?utm_source=knowledgecentre&utm_medium=ingredient_article&utm_campaign=grape_seed_extract&utm_content=navigation) [Instagram](https://www.instagram.com/petzpark "Instagram")[Facebook](https://www.facebook.com/petzpark "Facebook")[TikTok](https://www.tiktok.com/@petzpark "TikTok") © 2026 Petz Park. 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